T Cell Immunity Againt Sesonal and Pandemic Influenza Viruses

Grant number: 1023294 | Funding period: 2012 - 2015

Completed

Abstract

Introduction of a new influenza strain into human circulation leads to a rapid global spread of the virus (e.g. H1N1 2009 pandemic) due to minimal antibody immunity. Established T cell immunity towards conserved viral regions promotes rapid recovery. However, it is unclear what determines the effective T cell immunity towards influenza. We will define the optimal human T cell populations, with the ultimate goal of improving vaccine design so it protects against seasonal and pandemic strains.

Related publications (8)

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Erratum: Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians (Immunology and cell biology (2016) 94 4 (367-377))

EB Clemens, EJ Grant, Z Wang, S Gras, P Tipping, J Rossjohn, A Miller, SYC Tong, K Kedzierska

2017-08-01

This corrects the article DOI: 10.1038/icb.2015.93.

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Fc functional antibodies in humans with severe H7N9 and seasonal influenza

HA Vanderven, L Liu, F Ana-Sosa-Batiz, THO Nguyen, Y Wan, B Wines, P Mark Hogarth, D Tilmanis, A Reynaldi, MS Parsons, AC Hurt, MP Davenport, T Kotsimbos, AC Cheng, K Kedzierska, X Zhang, J Xu, SJ Kent

2017-07-06

BACKGROUND. Both seasonal and novel avian influenza viruses can result in severe infections requiring hospitalization. Anti-influe..

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Influenza-specific antibody-dependent phagocytosis

F Ana-Sosa-Batiz, H Vanderven, S Jegaskanda, A Johnston, S Rockman, K Laurie, I Barr, P Reading, M Lichtfuss, SJ Kent

2016-04-01

Background: Immunity to human influenza A virus (IAV) infection is only partially understood. Broadly non-neutralizing antibodies ..

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Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians

EB Clemens, EJ Grant, Z Wang, S Gras, P Tipping, J Rossjohn, A Miller, SYC Tong, K Kedzierska

2016-04-01

Indigenous populations, including Indigenous Australians, are highly susceptible to severe influenza disease and the underlying me..

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Avian influenza viruses, inflammation, and CD8 T cell immunity

Z Wang, L Loh, L Kedzierski, K Kedzierska

2016-03-01

Avian influenza viruses (AIVs) circulate naturally in wild aquatic birds, infect domestic poultry, and are capable of causing spor..

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Human influenza viruses and CD8 T cell responses

EJ Grant, SM Quinõnes-Parra, EB Clemens, K Kedzierska

2016-02-01

Influenza A viruses (IAVs) cause significant morbidity and mortality worldwide, despite new strain-specific vaccines being availab..

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Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses

S Jegaskanda, K Vandenberg, KL Laurie, L Loh, M Kramski, WR Winnall, K Kedzierska, S Rockman, SJ Kent

2014-12-01

Background. Intravenous immunoglobulin (IVIG) is a purified pool of human antibodies from thousands of donors that is used to prev..

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Influenza-specific antibody-dependent cellular cytotoxicity: Toward a universal influenza vaccine

S Jegaskanda, PC Reading, SJ Kent

2014-07-15

There is an urgent need for universal influenza vaccines that can control emerging pandemic influenza virus threats without the ne..

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